However, consumption of large quantities of the material may have a laxative effect. Microcrystalline Cellulose (MCC) Manufacturing Industry. 1.3. Microcrystalline cellulose is a commonly used excipient in the . It . Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. cas:9032-51-3 msds CELLULOSE PAB. 5 0 obj . It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. There have always been two different points of view for the liquidity of MCC. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Document(s): certificate data msds. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? : 160182. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Manufacturer: FMC BioPolymer. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. The figure below illustrates the structural organisation of cellulose within plants. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. PDF (4.11 mb) Footer menu 1. undefined. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. MATERIAL SAFETY DATA SHEET Version: 1.0 1. Microcrystalline Cellulose. LOT #: Available upon request. Truly distinctive drug delivery solutions. The data shown below apply only to Avicel PH 101. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. (1962). Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. 130. Manufactured by: China . SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Are you sure you want to delete your template? <> /Parent 3 0 R Revision No. 2021 Annual Report. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. AVICEL RC 581. q86@on$^X_HuH;3` /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Safety Data Sheet (SDS) Viewer. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. No. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Watch Now. It works as a moisture sponge and permits the controlled growth of spheroids. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. common form is used in vitamin supplements or tablets. Avicel PH-101. Microcrystalline Cellulose / Avicel PH-102. Revision No. Buy Chemicals. *r_ *?~4$ &0Y# When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Quick Links. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. There may be more fiber in your food than you realized. SDS. Magazine: Material safety data sheet - FMC Corporation. The aqueous solution to barrier membrane coating. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! FMC, JRS and Mingtai were estimated to hold for . 4. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. ( MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Van Veen, G.K. Bolhuis, Y.S. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Superior Performance: Provides excellent water uptake and rapid swelling . ChemicalBook. It is also used in plaque assays for counting. Product and Company Identification . A family of polysaccharide products that allow distinctive drug delivery solutions. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. It is also inert and biocompatible. gac74 [#B6`Wnw7 Test Data Available. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. CAS #: 9004-34-6 1 0 obj G2W4de=u183KGH{ vQ#4:1\wc : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. All rights reserved. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Report Category. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . This Microcrystalline Cellulose . All Rights Reserved. Well-recognized product that can do it all. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. We know that our customers need to provide reliable and consistent products to their patients. P}MFbN#[>r(y MATERIAL SAFETY DATA SHEET. JFIF ` ` ZExif MM * J Q Q Q C Biologicals by FMC. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. 8 0 obj Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . It is . >> Combines good flow and high compactibility. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Thus, Avicel contributes no or very few calories to the food system. endobj Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Your file is uploaded and ready to be published. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W <> B;vLZpHU%ChUyD+[ l~5C It is available in different grades and particle sizes. Are you looking for information about products and services by region? They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Microcrystalline Cellulose NF. : CL-611NF Date Approved: 01/13/2010. The most. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. It is, however, a good source of fibre. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. q9;v80q>jZ Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Created Date: 2/10/2020 8:51:41 PM . Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. stream Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. SUBSTANCE IDENTIFICATION 1.1. The short-term limit for total inhalable dust is 20 mg/m3. Synonyms: Cellulose, Cellulose powder, Cotton linters. EMCOCEL XLM 90. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Synergies to simplify formulation challenges and reduce operational costs. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Protect them from sunshine or rain. . Watch Now. However, it yields non-digestible fibre. MSDS Ref. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . 51395-75-6 Avicel RC 591. SCMm_>x^O9l (n. ( Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . CoA. Microcrystalline Cellulose; Cellulose; Functions. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. 3 0 obj Have an order or account question? stream Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Home. We can send by Fedex, by ship or by plane according to international rules. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. : 1. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. (&E. Avicel PC 611 Microcrystalline Cellulose. The typical mean particle size is 20200 m. : 160182 Date Approved: 05/25/2010 Revision No. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Powder becomes slippery when wet. 4 0 obj In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. In extrusion-spheronisation, it is the excipient of choice. <> Unique functionality for a broad range of pharmaceutical applications. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Avicel RC-591 & CL-611 - Description. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. 0.25 - 0.37. It is hygroscopic and insoluble in water. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Date Approved: 05/25/2010. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. The table below shows the most common physicochemical parameters of this raw material. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. SDS - Safety Data Sheet. Microcrystalline Cellulose / Avicel PH-102. endobj Delivering efficient and robust formulations. Explore how you can develop your career and bring your creative ideas to life at IFF. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. CAS 9004-34-6, pH 5 - 7.5. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. } !1AQa"q2#BR$3br PDF (2.77 mb) 2021 FMC Sustainability Report. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Page 1 of 8. POLYOX resins are nonionic polyethylene oxide solubility polymers. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Regulatory Information No. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) <> Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Microcrystalline Cellulose Side Effects. Terms and Conditions Compliance Solutions Industries About 3E News & Events . No. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . lH5JWy}DgKRR"Fs < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers.
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